Tristetraprolin Regulates CXCL1 (KC) mRNA Stability

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Tristetraprolin regulates CXCL1 (KC) mRNA stability.

mRNAs encoding proinflammatory chemokines are regulated posttranscriptionally via adenine-uridine-rich sequences (AREs) located in the 3' untranslated region of the message, which are recognized by sequence-specific RNA-binding proteins. One ARE binding protein, tristetraprolin (TTP), has been implicated in regulating the stability of several ARE-containing mRNAs, including those encoding TNF-a...

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ژورنال

عنوان ژورنال: The Journal of Immunology

سال: 2008

ISSN: 0022-1767,1550-6606

DOI: 10.4049/jimmunol.180.4.2545